Free Ebook Pharmaceutical Process Chemistry for Synthesis: Rethinking the Routes to Scale-Up, by Peter J. Harrington
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Pharmaceutical Process Chemistry for Synthesis: Rethinking the Routes to Scale-Up, by Peter J. Harrington
Free Ebook Pharmaceutical Process Chemistry for Synthesis: Rethinking the Routes to Scale-Up, by Peter J. Harrington
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There is a need to explain that generic versions of a drug may not be manufactured by the same process as brand-name drugs and that the different processes may have dramatically different environmental impacts. Two global forces are at odds today—the push for "greener" processes and the push for lower drug prices. This book brings this conflict into sharp focus by discussing in detail the published process chemistry for top-selling small molecule drugs.
Providing insights about process route selection, choice of reagents, and reaction conditions, Pharmaceutical Process Chemistry for Synthesis guides process chemists in identifying best processes for manufacturing these blockbuster drugs as they lose patent protection. Further, it highlights the strategies and methodology that might be useful for expediting the process research and development of the blockbusters of the future.
Written from a refreshingly objective perspective, this book is essential for process chemists who need to devise practical syntheses for increasingly complex drugs in a constantly decreasing time frame.
- Sales Rank: #3644032 in eBooks
- Published on: 2011-06-10
- Released on: 2011-06-10
- Format: Kindle eBook
Most helpful customer reviews
4 of 4 people found the following review helpful.
review for Harrington's "Pharmaceutical Process Chemistry for Synthesis"
By N A
Harrington's book contains a wealth of information, taken from the patent literature and from his decades of experience in process chemistry in the pharmaceutical industry. Through discussions on route selection he introduces practical aspects of route design, including selecting non-toxic, stable and inexpensive starting materials, reactions that minimize impurity contents with optimized yields, and ease of purification. Harrington lays out the various approaches to successful molecules, including biocatalysis, and sorts out which routes are acceptable, creative, likely to be the manufacturing route, or merely holding space.
Throughout his book Harrington discusses many practical points of process introduction. For instance: the preference of charging liquids over solids; reactor volume throughput typically preferred on scale; possible incompatibility of HCl salts with 316 SS reactors, and how drying solids under reduced pressure can break an azeotrope and extend drying time. He poses questions, some that an earnest student would follow and answer. Other questions might only be answered only by a researcher who worked on the particular compounds, but who did not necessarily describe all the details uncovered or developed.
Harrington's perspective is pragmatic: "Good science does not always make good business sense." He invested a great deal of energy in describing reactions and workups; such extremely detailed information can be mined for nuggets that the reader could potentially apply in their own work. For instance, many readers may be surprised that Ca or Na salts can be extracted into EtOAc.
Harrington's book will be extremely valuable for the process chemist who wants to delve deeply into details critical for route selection and process optimization, and for the student new to chemical process R&D in the pharmaceutical and CRO / CMO industries.
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